Metformin’s main site of action is at the liver to reduce the excessive sugar release seen in type 2 diabetes. Metformin does not cause weight gain, and is usually the first choice of medication to treat type 2 diabetes. However, if you have kidney or liver problems, heart failure, or are very sick, metformin cannot be used.Of course, those don't match at all. Metformin has a number of interesting and positive benefits:
Of course, weight loss is one of my goals. But there are others. It apparently delays or prevents type 2 diabetes (a subject of concern because my father developed diabetes in his 50s and my brother died from it). It apparently reduces cardiovascular disease although my physician pointed out that it is unclear if that is a consequence of metformin, or that it prevent diabetes, which increases cardiovascular disease.Metformin often promotes weight loss in patients with obesity with non-insulin-dependent diabetes mellitus (NIDDM). The mechanism may be attributed to decreased food intake. This study has tested the effect of metformin on satiety and its efficacy in inducing weight loss. Twelve diet-treated NIDDM women with obesity were randomly given two dose levels (850 mg or 1700 mg) of metformin or placebo at 0800 for three consecutive days followed by a meal test on the third day on three occasions using a 3x3 Latin square design. The number of sandwich canapes eaten in three consecutive 10-minute periods beginning at 1400 hours was used to quantitate food intake, and the level of subjective hunger was rated just before the sandwich meal with a linear analogue hunger rating scale at 1400 after a 6-hour fast.