Saturday, July 30, 2011

Need Data on Timed Release Prolixin Dosage Decay Curve

There is apparently a graph out there (or perhaps just data) that shows the decay curve of time released prolixin decanoate (fluphenazine decanoate  which is administered by deep intramuscular injection. It apparently (and unsurprisingly) takes a number of hours from injection to maximum blood level, and a number of more hours to decay to the level that provides the therapeutic effect.  During this rise and decay period, there are apparently substantial impairment effects that it has--although this description isn't very detailed about those impairment effects.

I am not having much luck finding that information on the rise and decay characteristics.

UPDATE: Thanks to the reader who pointed me in the right direction: R. H. Mindham, "Assessment of drugs in schizophrenia. Asessment of drug-induced extrapyramidal reactions and of drugs given for their control," Br J Clin Pharmacol. 1976 June; 3(3 Suppl 2): 395–400, available here for free. It indicates that the maximum effect of the unwanted side effects (the ones that make it hard to walk a line, or do other tasks involving coordination) is three to five days after injection.

2 comments:

Ex-ER Doc said...

http://www.ncbi.nlm.nih.gov/pubmed/2864156
Start with the link above. The search terms you need are all there. You can get the article from your nearest medical school library.

Ex-ER Doc said...

http://www.ncbi.nlm.nih.gov/pubmed/2864156
You may find what you need at the link above. In any event all the search terms you need are there. Get the article via your nearest med school library.