I suspect two provinces leaving would encourage Quebec separatists voting on again on this.
Alberta and Saskatchewan as independent nations makes little sense except if they had a free trade arrangement with the U.S. and participation in NORAD. I am not sure how much they could contribute. They could buy a small number of fighters (perhaps given by us) and participate in North American Air Defense. Central Canada would be pissed, but loss of Quebec might make the whole discussion moot.