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Saturday, March 6, 2021

Prostate Cancer

 I have a brother-in-law who had it.  A robot went in and did the laprascopic removal of the tumor.  It is still a major concern for all older men; fortunately, it grows slowly enough that for many men, it makes more sense to wait for death from other causes instead of surgery.  But what can you do to reduce your risk?

A variety of dietary and lifestyle factors appear to affect prostate cancer progression. Several generally widely recommended lifestyle factors such as not smoking, maintaining a healthy body weight, and regular vigorous physical exercise also appear to affect prostate cancer progression. Several dietary factors, such as tomato sauce/lycopene, cruciferous vegetables, healthy sources of vegetable fats, and coffee, may also have a role in reducing risk of prostate cancer progression.["Prostate cancer progression and mortality: a review of diet and lifestyle factors," World Journal of Urology]

This article attempted to figure out why black men are at higher risk of prostate cancer than white men:

Statistically significant risk factor-prostate cancer associations for overall disease were mainly evident for white men, with many risk estimates similar in magnitude but nonsignificant for black men (Table 2). This includes inverse associations with BMI, current and former smokers, and tomato consumption, and positive associations with alcohol and red meat consumption (Pinteraction> 0.05 for all factors) (Table 2). History of diabetes was the only factor statistically significant and similar in magnitude for white men (HR = 0.72, 95% CI: 0.69–0.76) and black men (HR = 0.77, 95% CI: 0.65–0.90, Pinteraction = 0.66). Whereas, the association with height qualitatively differed between white men (HR = 1.03, 95% CI:1.01–1.04) and black men (HR = 0.91, 95% CI:0.85–097, Pinteraction = 0.003) (Table 2). ["Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study," Prostate Cancer Prostatic Dis] 

A number of other studies emphasize obesity as an important risk factor.  This study is one to wave under your wife's nose

Results During 222 426 person-years of follow-up, there were 1449 new cases of total prostate cancer, 953 organ-confined cases, and 147 advanced cases of prostate cancer. Most categories of ejaculation frequency were unrelated to risk of prostate cancer. However, high ejaculation frequency was related to decreased risk of total prostate cancer. "Ejaculation Frequency and Subsequent Risk of Prostate Cancer," JAMA]

 

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